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KMID : 1161519970010020381
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Animal Cells and Systems
1997 Volume.1 No. 2 p.381 ~ p.388
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Localization of glutamate-immunoreactive neural elements in the dog basilar pons
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Lee Hyun-Sook
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Abstract
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Glutamate is a putative excitatory neurotransmitter in the central nervous system. The present study utilizing monoclonal antibodies against fixative?modified glutamate analyzed the distribution of glutamate?immunoreactive neuronal elements in the dog basilar pons. The glutamatergic neurons were present throughout the rostrocaudal extent of the basilar pons, predominantly to the medial and ventral subdivisions. Labelled cells were relatively sparse in the midline region of the medial nucleus and most lateral area of the lateral nucleus. The majority of glutamate?immunoreactive neuronal somata in the basilar pons was multipolar?shaped, and the size was in the range of 15?25 μm in diameter. Glutamate?immunoreactive axons and terminals were also observed at specific regions of the basilar pons. These observations provide evidence that this excitatory neural element functions in a multisynaptic pathway involving glutamatergic afferents to the basilar pons, pontocerebellar projection neurons, and the granule cells of the cerebellar cortex.
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KEYWORD
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Basilar pontine nuclei, Glutamate, Immunocytochemistry
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